Sheila Jacobs

Kinase inhibition or allele-specific targeting of mutant LRRK2 may still be a meaningful target for therapeutic development.

This widespread variation in strategies may contribute to undesirable outcomes that are characterized by poor seizure control and added deficits.

The studies that included neurocognitive measures demonstrated no significant difference between the use of rTMS and sham-rTMS.

The investigators sought to explore how aortic stiffening is linked to resting cerebral blood flow and cerebrovascular reactivity in older adults.

The findings offer some reassurance for clinicians and for pregnant women who are successfully treated with enzyme-inducing ACDs.

The root causes of the disparity reported among families of different income levels are unclear and deserve additional investigation.

The results of this review are applicable primarily to persons with focal onset seizures, with 88% of included participants experiencing this type of seizure at baseline.

Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.

The investigators sought to evaluate whether early-life traumatic experiences, stressful life events, and alexithymia are associated with chronic migraine and medication overuse headache.

Lower cognitive ability total and verbal ability scores were predictive of greater risk for early-onset dementia.

The investigators sought to evaluate the efficacy and safety of mindfulness-based stress reduction and mindfulness-based cognitive therapy in the reduction of the symptoms associated with chronic headaches.

The efficacy was reported to be significantly higher in patients who had taken benzodiazepines.

The prospective study was performed in patients ≥16 years of age with community-acquired bacterial meningitis.

A team of investigators sought to assess the efficacy and safety of cilostazol vs aspirin, both with and without probucol, a cholesterol-lowering agent, in Asian patients with ischemic stroke.

A team of investigators sought to assess whether the use of diagnostic transcranial Doppler ultrasound may delay initiation of intravenous thrombolysis in patients experiencing acute stroke.

Although patients with idiopathic and 22q11.2 DS forms of Parkinson disease had a similar age at disease onset, the diagnosis of PD was delayed significantly in patients who had a history of antipsychotic therapy.

Measurement of the disease protein huntingtin in saliva may be promising as an accessible, noninvasive biomarker to predict symptom severity and disease course in individuals with Huntington disease.

Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

A majority of the respondents in both groups identified reduced disability progression as a priority.

No significant association among closing pressure, amount of CSF removed, and time to resolution of papilledema is reported in patients with PTCS.

In the discovery stage, genome-wide and logistic and linear regression analyses were performed to examine the association of genetic variants with risk for disease and age at onset in those with a GRN mutation and controls who were free of neurodegenerative disorders.

The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.

The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.

The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.

The investigators sought to compare NfL and tau as blood biomarkers for acute SRC and to establish whether their concentrations at various time points following the injury are linked to prolonged time to return to play.

Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.

Researchers explored potential sex-based differences in ranking at academic neurology programs.

Researchers evaluated the use of genetic screening to identify individuals who are at risk for carbamazepine-induced cutaneous adverse drug reactions.

Additional examination of these relationships is warranted to help clarify the complex biologic and psychosocial interactions among Alzheimer disease, malignant melanoma, and nonmelanoma skin cancer.

Among pregnant women with Zika virus infection, birth defects were reported more often in fetuses and infants whose mothers had been infected with the virus early in their pregnancies.