Cholesterol delivery to the brain is a therapeutic option to reverse the behavioral decline related to Huntington disease, a study found.
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The interaction between soluble forms of mutant huntingtin protein and key cellular organelles drives the initial steps of Huntington disease progression.
Ingrezza has demonstrated consistently greater improvements in adults with chorea associated with HD from week 2 to 12 vs placebo.
Neurocrine Biosciences announced FDA approval for the use of valbenazine (Ingrezza®) to alleviate chorea in patients with Huntington disease.
In a large, population-based case-control study, researchers identified prescription medications associated with a lower risk for 3 neurodegenerative diseases: Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis.
Valbenazine results in improvement in chorea compared with placebo for patients with Huntington disease, according to a study.
Xanthine dehydrogenase/oxidase blockers may reduce the risk for neurodegenerative diseases, according to a study.
Researchers sought to identify the clinical and cognitive differences at baseline between patients with autopsy confirmed limbic predominant age-related TDP-4 (LATE) and patients with AD and comorbid LATE+AD.
Researchers sought to characterize trends in pathways underlying dementia by assessing the prevalence of postmortem neuropathologies in birth cohorts over a period of 25 years.
Soccer players, specifically outfield players, have an increased risk for neurodegenerative disease, according to a study.
Researchers sought to examine potential associations between viral exposures and neurodegenerative disease risk.
Researchers compared cognitive and functional measures in individuals who subsequently developed AD, PD, FLD, PSP, LBD, or MSA with individuals without neurodegenerative diagnoses.
Tofersen is an investigational antisense medicine that reduces the synthesis of SOD1 protein production by binding to SOD1 mRNA, allowing for its degradation by RNase-H.
In a cross-sectional genetic association study, researchers evaluated whether APOEε4 may play a role in CTE.
Researchers sought to provide a biological definition for HD and assess the progression of HD from birth to death through developing an evidence-based staging framework.
The biomarker test measures NfL levels through standard blood collection.
Researchers sought to compare the CSAmn in patients with ALS and control individuals, and analyze the role of CSAmn as a progression and prognostic biomarker of the disease.
Researchers sought to categorize patients with amyotrophic lateral sclerosis with the Gold Coast Criteria to evaluate its potential use in clinical trial recruitment.
The oral suspension can be administered by mouth or via feeding tube using a 5 mL oral syringe that comes with the product.
In a phase 3 trial, researchers assessed the safety and efficacy of ultra-high dose methylcobalamin in slowing functional decline in patients with ALS.
Researchers sought to provide insight into the potential effect of treatment crossover in the placebo group on the estimated survival effect of sodium phenylbuturate and taurursodiol.
Researchers sought to examine the association between the number of important subcortical wake-promoting neurons and clinical sleep phenotypes in patients with AD or PSP.
In a close vote, an advisory panel for the US Food and Drug Administration decided not to recommend the approval of an experimental drug for amyotrophic lateral sclerosis (ALS).
Researchers sought to assess the incidence of spinal cord gray matter atrophy in patients with post-polio syndrome and its associations with muscle strength and functional decline.
Smoking is associated with higher odds of being diagnosed with multiple sclerosis (MS), and high alcohol intake is associated with retinal features indicative of more severe neurodegeneration in individuals with MS.
Researchers sought to investigate the association between serum asymmetric dimethylarginine (ADMA) levels and the progression and prognosis of amyotrophic lateral sclerosis, and to compare cerebrospinal fluid and serum ADMA levels with other ALS biomarkers.
In a retrospective study, researchers assessed the predictive value or serum lipid profiles on the basis of gender and hypermetabolism in patients with ALS.
In a cohort analysis in the UK biobank, researchers assessed the association between individuals with previous neurodegenerative diseases and the subsequent risk for COVID-19.
Researchers sought to estimate incidence rates and case counts of amyotrophic lateral sclerosis in the US from 2014 through 2016 using administrative and self-reported databases.
In a retrospective analysis, researchers assessed blood biomarkers of neurodegeneration in patients hospitalized for COVID-19 without a history of dementia.
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