Research suggests a dramatically increased risk of developing dementia among older patients with major depressive disorder, particularly those who are resistant to antidepressant medication.

ALTO-101 is an investigational phosphodiesterase-4 inhibitor delivered via a transdermal patch.

The SC formulation is supplied as a 360mg/1.8mL single-dose prefilled autoinjector.

The International Society for Vascular Behavioural and Cognitive Disorders working group updated the vascular cognitive impairment and dementia diagnostic criteria.

The investigational agent is a humanized monoclonal antibody that targets multiple domains of the microtubule binding region of tau.

A study was conducted to determine the impact of cognitive impairment on the development of incident clinical heart failure.

Researchers describe the association between late-life TBI, incident dementia, and health care needs among community-dwelling individuals older than 65 years.

Researchers assessed national trends in self-reported cognitive disability using Behavioral Risk Factor Surveillance System data.

The American Heart Association estimated the incidence and prevalence of vascular contributions to cognitive impairment and dementia in the United States.

Researchers examined the relationship between chronic insomnia and cognitive decline in older adults.

Researchers examined the association between alcohol consumption and dementia in 2 large-scale population-based cohorts.

Researchers conducted a prospective cohort study based on UK Biobank participants without dementia to examine the link between physical frailty and dementia.

Researchers explored whether various metformin-based oral combination therapies influence risk for dementia in patients newly diagnosed with type 2 diabetes mellitus.

Researchers conducted a comprehensive literature review, including randomized controlled trials and observational studies comparing estrogen therapy to placebo or no treatment in postmenopausal women.

Researchers examined associations between PM2.5 exposure, dementia severity, and dementia-associated neuropathologic change.

Researchers conducted a multicenter cohort study to assess the neuroprotective effects of metformin among patients with obesity.

Researchers evaluated the relationship between depression and regional brain volumes in older adults from the National Alzheimer’s Coordinating Center database.

Investigators examined whether childhood loneliness is associated with cognitive decline and dementia risk in a cohort study using data from the China Health and Retirement Longitudinal Study.

Researchers assessed absolute and relative concentration–response associations between fine particulate matter exposure and Alzheimer Disease risk.

Researchers evaluated the relationship between sex and mortality and health care utilization among patients with dementia.

A study was conducted to assess if increased genetic risk for CAD is associated with long-term risk for developing dementia.

Researchers assessed the odds of dementia (all types) among individuals with several psychiatric disorders and identified relevant co-occurrence patterns.

Investigators evaluated whether AD is associated with alterations in NF and evaluated its predictive utility for AD conversion.

Researchers examined whether lifestyle interventions delay or prevent cognitive decline and dementia in older adults.

Researchers investigated whether a sense of life purpose reduces the risk for or delays the onset of cognitive impairment.

Researchers examined the effect of receiving a dementia diagnosis on social support needs.

The approval for SC injection was based on data from the open-label extension of the phase 3 CLARITY AD trial.

Researchers conducted a cross-sectional observational cohort study using baseline data from the Canadian Longitudinal Study of Aging.

Researchers conducted a concept analysis of processing speed in relation to the cognitive function of patients with cancer.