Researchers integrated genetic, plasma metabolomic, and dietary data from 4215 women and 1490 men in prospective cohorts to identify genome-specific metabolic pathways and modifiable risk factors of AD/ADRDs.

Researchers evaluated the effect of amyloid positron emission tomography imaging on clinical decision-making in diverse patient groups.

Researchers examined the association between macronutrient consumption, vascular brain injury, and cognitive performance.

Researchers conducted a prospective association study to examine whether hearing aid use by people with HL is associated with a lower risk for incident dementia in the Framingham Heart Study original and offspring cohorts.

A multidisciplinary panel evaluated the accuracy of blood-based biomarker tests for Alzheimer disease, and issued evidence-based recommendations.

Researchers evaluated the relationship between postoperative delirium following noncardiac surgery and major complications in patients aged 65 years and older.

Researchers examined the association between amyloid-beta pathology and cognitive performance in centenarians.

Researchers conducted a multicenter cohort study to investigate whether metformin use was associated with a lower long-term incidence of dementia and all-cause mortality in patients with overweight or obesity.

Researchers examined the relationship between nucleoside reverse transcriptase inhibitor exposure and the development of Alzheimer Disease.

Researchers examined long-term associations between mode of transportation and young-onset and late-onset dementia.

Researchers conducted a cross-sectional study examining trends in home-based care among Medicare beneficiaries with vs without dementia.

Investigators conducted a systematic review of quantitative studies on TTD in dementia and factors associated with its duration.

Researchers estimated lifetime risk for dementia across population subgroups, and projected the number of new dementia diagnoses in the US over the next 4 decades.

The phase 1b PRECISE-AD trial is currently investigating PMN310 in patients with mild cognitive impairment due to AD and in those with mild AD.

Researchers compared the effects of 2 2-year lifestyle interventions on the cognitive trajectory in older adults at risk for cognitive decline and dementia.

Investigators conducted a systematic literature review and meta-analysis to assess the link between outdoor air pollution and the risk for dementia.

In a large, population-based study, researchers investigated whether breast cancer survivors have a reduced risk for Alzheimer dementia and examined how cancer treatments may influence this risk.

Researchers conducted a systematic review and meta-analysis to assess dementia and mortality risks among patients with hypothyroidism.

Researchers examined the association of semaglutide and tirzepatide with the incidence of dementia, Parkinson disease, ischemic stroke, intracerebral hemorrhage, and all-cause mortality compared to other antidiabetic drugs in a retrospective cohort study.

In a retrospective cohort study, researchers examined the geographic differences in dementia incidence among US veterans aged 65 years and older.

Investigators conducted a retrospective cohort study using data from a global health research network between 2004 and 2024 to examine the comparative effectiveness of GLP-1 RAs and metformin in reducing dementia risk.

Investigators compared the effect of GLP-1 RAs to DPP4is as second-line therapy for type 2 diabetes on the risk for dementia in a target trial emulation.

In an observational, retrospective cohort study, researchers assessed whether semaglutide is associated with a decreased risk of developing dementia.

In a population-based cohort study, researchers determined whether metabolic syndrome and its individual components increase the risk for young-onset dementia, including all-cause dementia, Alzheimer disease, and vascular dementia.

Researchers conducted a retrospective cohort study to examine whether gabapentin prescription is associated with dementia in adults with chronic low back pain.

The amended titration schedule was based on the randomized, double-blinded TRAILBLAZER-ALZ 6 trial.

Researchers conducted a retrospective, nationwide study between 2015 and 2021 to examine the incidence and prevalence of dementia among US Medicare beneficiaries.

Researchers evaluated the association between regular use of opioids and incident dementia risk among patients with chronic noncancer pain.

Researchers examined how neighborhood disadvantage relates to core AD pathology, neurodegeneration, and inflammatory biomarkers in community-dwelling older adults who underwent fasting blood and CSF acquisition serially during a 9-year follow-up period.

Researchers conducted a retrospective study to examine insulin resistance as a progression marker in patients with a cerebral spinal fluid-based diagnosis of AD or other neurodegenerative diseases who were nondiabetic.